Spondyloarthropathy is a family of seronegative inflammatory rheumatic diseases of the spine–with the term “seronegative" connoting that the patient in question is negative for rheumatoid factor and antinuclear antibodies in the bloodstream. The main forms of seronegative spondyloarthropathy are ankylosing spondylitis, reactive arthritis (for example, Reiter’s syndrome), psoriatic arthritis and the spinal disorders associated with inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis.
Spondyloarthropathy is characterized by back pain and stiffness, and in some cases systemic manifestations affecting the eyes, gastrointestinal tract, and skin. Spondyloarthropathy is associated with joint inflammation and cartilage destruction, which leads to immobility in the musculoskeletal system. Although not detectable with routine blood tests for common antibodies, spondyloarthropathy, especially ankylosing spondylitis, is associated with a higher prevalence of the human leukocyte antigen B27 (HLA-B27) gene.
Structure and Function
Spondyloarthropathy results in joint inflammation and cartilage destruction, which results in pain and loss of motion at the affected joint. In the spine, this is manifest as inflammation of the annulus surrounding the nucleus pulposus of the intervertebral disc, with subsequent bone formation. Bone formation within the intervertebral disc, so-called syndesmophytes, (calcification of the intervertebral disc) can ultimately fuse one vertebral body to another, leading to ankyloses (fusion) of the spine.
Inflammation of the attachment of the longitudinal ligaments also promotes soft-tissue ossification which contributes to the fusion of otherwise normally mobile segments. Spondyloarthropathy can induce synovitis affecting the facet joints between adjacent articular processes.
There is a strong susceptibility to spondyloarthropathy in people with the human leukocyte antigen B27 (HLA-B27) phenotype. Human leukocyte antigens are part of the major histocompatibility complex. Their function is to present antigens to cytotoxic T cells. Thus, the mechanism by which HLA-B27 predisposes individuals to develop spondyloarthritis likely involves an auto-immune reaction initiated by a response to an environmental factor or infectious pathogen, though the exact process remains unresolved.
In ankylosing spondylitis, the sacroiliac joint and the pubic symphysis are the most commonly affected joints in the body. Further inflammation leads to ascending fusion of the vertebrae of the lumbar, thoracic, and cervical spine, ultimately resulting in a “bamboo spine” appearance on x-ray.
Reactive arthritis, as the name suggests, is thought to occur as a reaction to a foreign insult, often due to viruses, chlamydia, or certain bacteria including Yersinia, Salmonella, Shigella, and Campylobacter. While reactive arthritis can affect the spine, it can also commonly affect other joints of the body.
Psoriatic arthritis occurs in patients with psoriasis. In a small set of patients, the classic skin findings may be absent at the onset of joint symptoms, although many of these patients will eventually develop the characteristic rash.
Patients with inflammatory bowel disease often have spondyloarthropathy. In one 20-year prospective cohort study of approximately 500 patients with ulcerative colitis or Crohn’s disease, ankylosing spondylitis developed in about 5% of patients, and inflammatory back pain without the findings of ankylosing spondylitis in nearly 20% more. (Notably, the bowel disease was worse in patients who have spondyloarthropathy as well.)
The prototypical presentation of ankylosing spondylitis is a male in his 20s complaining of lower back pain and stiffness of insidious onset. This pain is worse in the morning and improves with activity, in contrast to osteoarthritis, which is relieved with rest and worsens with activity.
On physical exam, decreased spine motion in the anterior-posterior plane is most evident. The Schober test (Figure 3) can be used to evaluate lumbar stiffness.
Pain with the FABER maneuver (Figure 4) can help localize symptoms to the sacroiliac joint. This test is performed by placing the supine patient’s hip in a position of flexion, abduction and external rotation, and having the examiner press on the flexed knee toward the pelvis, thereby loading the sacroiliac joint.
Advanced ankylosing spondylitis is associated with a disabling thoracolumbar kyphotic deformity in more than 30 % of cases. In advanced cases, ankylosis of the rib case and thoracic spine will limit chest wall expansion. Total chest wall expansion of less than 2cm (normal = 2.5-5.0cm) is considered diagnostic. When chest wall expansion is limited, the patient may feel shortness of breath.
Patients with reactive arthritis classically have a triad of findings: conjunctivitis, urethritis, and arthritis (with the arthritis often occurring later in the course than the other two symptoms). In many cases, patients can recall a history of recent viral or bacterial infection 1 to 3 weeks prior to the onset of other symptoms.
A distinctive feature of reactive arthritis is dactylitis, in which one or two fingers or toes becomes diffusely swollen. A small fraction of patients (< 10%) present with cardiac manifestations of the disease, such as aortic regurgitation or pericarditis.
Psoriatic arthritis most commonly affects the limbs, but in <40% of cases, the cervical spine or the sacroiliac joint can be affected. Most of the patients have a history of psoriatic rash (Figure 5) prior to the appearance of arthritis, some develop the rash and arthritis concurrently and others present with arthritis first.
Enthesopathies involving the Achilles tendon, patellar tendon and plantar fascia are often seen.
Extra-articular manifestations are common with spondyloarthropathies. Uveitis (Figure 6) is the most frequent extra-articular manifestation of ankylosing spondylitis, occurring in ~25% of patients. This presents as acute, unilateral eye pain, accompanied by blurry vision, photophobia, and increased production of tears (“lachrymation”).
There are no specific serological tests for seronegative spondyloarthropathies. Elevation of the erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) levels are suggestive of inflammation, but are non-specific. The tests for rheumatoid factor (RF) and anti-nuclear antibody (ANA) are, by definition, normal in seronegative spondyloarthropathy. The synovial fluid may also show an increased preponderance of white blood cells, neutrophils in particular, but this finding is also nonspecific.
While there is a strong correlation to the HLA-B27 gene, only a scant minority (1-2%) of those with the HLA-B27 gene ever develop spondyloarthropathies. The prevalence of HLA-B27 varies by race ethnicity and location; in the United States, the estimated prevalence is about 7% among Caucasians, but less than 1% among African Americans. Only 10% of patients with spondyloarthropathies test negative for the HLA-B27 gene. Taken together, testing for the HLA-B27 gene is neither sensitive nor specific enough to make definitive diagnoses.
In patients with suspected ankylosing spondylitis, full-length AP and lateral plain radiographs of the spine and pelvis should be obtained.
Sacroiliac erosions and joint space changes are characteristic and are the first radiographic features observed (Figure 7).
Another common finding is the presence of syndesmophytes that connect the vertebral bodies (as shown above).
MRI is the best modality for early detection of ankylosing spondylitis, as it can detect inflammation around the sacroiliac joints on the T2-weighted images.
The prevalence of the spondyloarthropathies varies widely by disease type, patient race and geography.
Ankylosing spondylitis affects males approximately 3 to 4 times more frequently than it affects females. The typical age of onset is adulthood. The HLA-B27 gene is present in ~90% of patients. Overall, about 0.2% of patients in the USA are affected.
Reactive arthritis is slightly less common (about 0.1% of US citizens are affected) but there is a similar strong predominance of male patients, and the typical age of onset is also in early adulthood. The HLA-B27 gene is present in ~80% of patients.
Psoriatic arthritis is found in about 0.3% of Americans. Unlike ankylosing spondylitis and reactive arthritis, psoriatic arthritis has a later age of onset (about 40 years of age) and an equal distribution among males and females.
As noted above, about 25% of patients with inflammatory bowel disease will have some form of spondyloarthropathy, but most cases do not feature sacroiliac erosions or ankylosis.
As most of the spondyloarthropathies affect younger patients, traumatic injuries should be ruled out initially. Aside from trauma which can be gleaned from a thorough history, there are other causes of non-traumatic injuries that may present in a similar manner to seronegative spondyloarthropathies.
While rare in young patients, osteoarthritis may be present,
especially in the context of repetitive trauma, overuse or genetic
predisposition. The defining features that help identify osteoarthritis are radiographic
findings consistent with joint space narrowing, osteophyte formation, bony
sclerosis, back pain that worsens as the day progresses, and the lack of inflammatory
markers on blood testing.
Rheumatoid arthritis is much more common than seronegative spondyloarthropathies and thus when inflammatory markers on blood testing are elevated and the patient’s back pain improves as the day progresses, rheumatoid arthritis must be considered. Notably, rheumatoid arthritis in the limbs is commonly symmetric, whereas peripheral joint involvement in spondyloarthropathies is often asymmetric. Most importantly, patients with spondyloarthropathy will test negative for rheumatoid factor and anti-nuclear antibody.
Diffuse Idiopathic Skeletal Hyperostosis (“DISH”) is also a condition that can cause enthesophytes and markedly decreased range of motion of the spine. This can be differentiated from ankylosing spondylitis by the location and shape of the bony outgrowths on radiographs. Syndesmophytes are bony fusions within the joint space itself, while enthesophytes occur outside the annulus fibrosus (Figure 8). Another key distinction is that DISH has no sacroiliac joint involvement and is a disease of older men; DISH is rarely seen in patients younger than 50 years of age.
The most concerning spondyloarthropathy is ankylosing spondylitis, as it can severely reduce the patient’s life expectancy and quality due to the eventual restriction of chest wall movement, mobility, susceptibility to complex fracture patterns after minor trauma, and overall spinal alignment. (Reactive arthritis and psoriatic arthritis, while painful, usually do not affect the patient’s life expectancy.) Thus, when a young man with no history of trauma presents with insidious lower back pain, ankylosing spondylitis must not be missed. The red flags suggesting ankylosing spondylitis include low back pain in a young patient with no history of recent trauma or repetitive stress; symptoms that improve during the day and with activity; and migration of the pain from the lumbosacral region towards the neck over time. In addition, radiographs of the pelvis have the characteristic pattern of sacroiliac joint fusion.
Among patients with known spondyloarthropathy, the syndesmophytes present render the spine brittle and minimally compliant. Thus, patients with ankylosing spondylitis are highly susceptible to unstable spine fractures and neurologic injury with low energy trauma. Diagnostic vigilance and a high index of suspicion for fracture must be maintained when evaluating a patient with known ankylosing spondylitis after trauma. CT and/or MRI are needed and the patient should be immobilized in their preinjury alignment pending diagnosis and treatment. Acute neck pain in a patient with long-standing ankylosing spondylitis should be immobilized and evaluated with more advanced imaging such as CT and MRI scans to exclude a fracture, even without a history of severe trauma.
Treatment Options and Outcomes
Treatment for spondyloarthropathies begins with traditional NSAIDs or COX-2 inhibitors; physical therapy is prescribed to maintain mobility and reduce pain. (NSAIDs must be used cautiously, if any at, in cases of spondyloarthropathy associated inflammatory bowel disease.)
Seronegative spondyloarthropathies, in general, are chronic and insidious diseases. Reactive arthritis may be the exception, as most cases are either self-limited or relapsing-remitting. The majority of reactive arthritis patients have severe symptoms lasting weeks to months that eventually disappear. However, about 15% of patients may develop chronic or progressive arthritis.
For patients who do not respond sufficiently to NSAIDs/COX-2 inhibitors (or for those who have complications compelling their cessation), biological response modifiers and disease-modifying antirheumatic drugs (DMARDs) may be considered. Biological response modifiers aim to block the interaction between inflammatory cells and include agents such as infliximab or etanercept, which are TNF-alpha inhibitors, or IL-12 inhibitors. DMARDs include methotrexate, cyclosporine, azathioprine, and sulfasalazine. DMARDs produce their immunosuppressive effects by suppressing the growth and maturation of inflammatory cells.
Debilitating kyphotic deformities in ankylosing spondylitis can be treated with an osteotomy and fusion (Figure 9).
Patients with advanced spondyloarthropathies are at risk for spinal fractures, most commonly in the mid-cervical or the cervicothoracic junction or lower at the thoracolumbar junction. While stable fractures with no accompanying epidural hemorrhage can be treated with traction or halo immobilization devices alone, instability, hemorrhage and neurological changes suggest a need for surgical intervention. The most common technique involves decompression at the site of injury to remove the hematoma, followed by spinal fusion to stabilize the area. In some cases, osteotomies are necessary to correct severe kyphotic deformities.
Risk Factors and Prevention
Spondyloarthropathy is a risk factor for spinal fracture and spinal cord injury. Indeed, the incidence of spinal cord injury among patients with ankylosing spondylitis is more than 10 times greater than that of the general population.
There are no known preventive measures for seronegative spondyloarthropathies. Although viral or bacterial infections are associated with reactive arthritis in HLA-B27 positive patients, any small infection may lead to the development of arthritis, making it difficult to prevent.
It is particularly important that patients with spondyloarthropathy, especially ankylosing spondylitis, stop smoking. The disease itself can create shortness of breath; the patient does not need other reasons on top of that.
For patients with spondyloarthropathy, exercises that focus on increasing flexibility with low impact such Pilates or Tai Chi may improve function.
Seronegative spondyloarthropathy, ankylosing spondylitis, reactive arthritis, bamboo-spine
Perform a comprehensive history and physical exam in patients presenting with back pain. Recognize the x-ray findings in spondyloarthropathy.